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Validation of resonance Raman spectroscopy-measured skin carotenoid status as a biomarker for fruit and vegetable intake in Korean adults

Published online by Cambridge University Press:  15 May 2023

Seoeun Ahn Open the ORCID record for Seoeun Ahn [Opens in a new window] ,
Sungmo Ahn ,
Hyeongseok Jang ,
Kunsun Eom Open the ORCID record for Kunsun Eom [Opens in a new window] ,
Yoon Jae Kim Open the ORCID record for Yoon Jae Kim [Opens in a new window] ,
Jeong-Eun Hwang Open the ORCID record for Jeong-Eun Hwang [Opens in a new window] ,
Ji In Chung ,
Jin-Young Park Open the ORCID record for Jin-Young Park [Opens in a new window] ,
Sunghyun Nam Open the ORCID record for Sunghyun Nam [Opens in a new window]  and
Yoon-Ho Choi Open the ORCID record for Yoon-Ho Choi [Opens in a new window]
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Seoeun Ahn
Affiliation:
Department of Public Health Science, Graduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea
Sungmo Ahn
Affiliation:
Advanced Sensor Lab, Samsung Advanced Institute of Technology (SAIT), Samsung Electronics Co., Ltd., Suwon 16678, Republic of Korea
Hyeongseok Jang
Affiliation:
Advanced Sensor Lab, Samsung Advanced Institute of Technology (SAIT), Samsung Electronics Co., Ltd., Suwon 16678, Republic of Korea
Kunsun Eom
Affiliation:
Advanced Sensor Lab, Samsung Advanced Institute of Technology (SAIT), Samsung Electronics Co., Ltd., Suwon 16678, Republic of Korea
Yoon Jae Kim
Affiliation:
Advanced Sensor Lab, Samsung Advanced Institute of Technology (SAIT), Samsung Electronics Co., Ltd., Suwon 16678, Republic of Korea
Jeong-Eun Hwang
Affiliation:
Department of Public Health Science, Graduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea Advanced Sensor Lab, Samsung Advanced Institute of Technology (SAIT), Samsung Electronics Co., Ltd., Suwon 16678, Republic of Korea
Ji In Chung
Affiliation:
Center for Health Promotion, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea
Jin-Young Park*
Affiliation:
Advanced Sensor Lab, Samsung Advanced Institute of Technology (SAIT), Samsung Electronics Co., Ltd., Suwon 16678, Republic of Korea
Sunghyun Nam*
Affiliation:
Advanced Sensor Lab, Samsung Advanced Institute of Technology (SAIT), Samsung Electronics Co., Ltd., Suwon 16678, Republic of Korea
Yoon-Ho Choi*
Affiliation:
Center for Health Promotion, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea
Hyojee Joung*
Affiliation:
Department of Public Health Science, Graduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea Institute of Health and Environment, Seoul National University, Seoul 08826, Republic of Korea
*
*Corresponding authors: Jin-Young Park, email jya.park@samsung.com; Sunghyun Nam, email sh303.nam@samsung.com; Yoon-Ho Choi, email yh38.choi@samsung.com; Hyojee Joung, email hjjoung@snu.ac.kr
*Corresponding authors: Jin-Young Park, email jya.park@samsung.com; Sunghyun Nam, email sh303.nam@samsung.com; Yoon-Ho Choi, email yh38.choi@samsung.com; Hyojee Joung, email hjjoung@snu.ac.kr
*Corresponding authors: Jin-Young Park, email jya.park@samsung.com; Sunghyun Nam, email sh303.nam@samsung.com; Yoon-Ho Choi, email yh38.choi@samsung.com; Hyojee Joung, email hjjoung@snu.ac.kr
*Corresponding authors: Jin-Young Park, email jya.park@samsung.com; Sunghyun Nam, email sh303.nam@samsung.com; Yoon-Ho Choi, email yh38.choi@samsung.com; Hyojee Joung, email hjjoung@snu.ac.kr
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Abstract

Blood carotenoid concentration measurement is considered the gold standard for fruit and vegetable (F&V) intake estimation; however, this method is invasive and expensive. Recently, skin carotenoid status (SCS) measured by optical sensors has been evaluated as a promising parameter for F&V intake estimation. In this cross-sectional study, we aimed to validate the utility of resonance Raman spectroscopy (RRS)-assessed SCS as a biomarker of F&V intake in Korean adults. We used data from 108 participants aged 20–69 years who completed SCS measurements, blood collection and 3-d dietary recordings. Serum carotenoid concentrations were quantified using HPLC, and dietary carotenoid and F&V intakes were estimated via 3-d dietary records using a carotenoid database for common Korean foods. The correlations of the SCS with serum carotenoid concentrations, dietary carotenoid intake and F&V intake were examined to assess SCS validity. SCS was positively correlated with total serum carotenoid concentration (r = 0·52, 95 % CI = 0·36, 0·64, P < 0·001), serum β-carotene concentration (r = 0·60, 95 % CI = 0·47, 0·71, P < 0·001), total carotenoid intake (r = 0·20, 95 % CI = 0·01, 0·37, P = 0·04), β-carotene intake (r = 0·30, 95 % CI = 0·11, 0·46, P = 0·002) and F&V intake (r = 0·40, 95 % CI = 0·23, 0·55, P < 0·001). These results suggest that SCS can be a valid biomarker of F&V intake in Korean adults.

Keywords

Skin carotenoidsFruits and vegetablesResonance Raman spectroscopyBiomarkerValidation
Type
Research Article
Information
British Journal of Nutrition , Volume 130 , Issue 11 , 14 December 2023 , pp. 1993 - 2001
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Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of The Nutrition Society

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Footnotes

†

These authors contributed equally to this work.

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